ASCO Highlights

Exelixis and Sanofi-aventis Collaborate for Discovery of PI3K Inhibitors

Sanofi-aventis and Exelixis signed a global licensing and collaboration agreement...

Acquisition of CuraGen Corporation by Celldex Therapeutics

Celldex Therapeutics announced that it has entered into a definitive agreement ...

Takeda to Acquire IDM Pharma, Adding MEPACT

Takeda Pharmaceutical Company and IDM Pharma announced that Takeda America ...

AstraZeneca and Merck to Investigate Novel Combination Anticancer Regimen

AstraZeneca and Merck announced a collaboration to research a novel...

Ligand-Independent HER2/HER3/PI3K Complex Disruption by Trastuzumab

Nearly 1/5th of breast tumors possess the 17q11-24 ErbB2-containing ...

Non-genetic Origins of Cell-to-cell Variability in TRAIL-induced Apoptosis

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is ...

Novel Strategies for Combating CRPC

The androgen receptor (AR), a key transcription factor, is directly ,..

STK33 as a Target for Treatment of Mutant KRAS-driven Cancers

Efforts to develop drugs that inhibit oncogenes such as RAS ...

Long-Term Durability of Ceplene in Sustaining Leukemia-Free Survival

EpiCept Corporation has released long-term data showing that the use ...

Positive Phase II Data of OGX-011 in Advanced Prostate Cancer Trial

OncoGenex Pharmaceuticals announced the final results of a randomized ...

Everolimus Phase II Positive Results in Lymphoma Patients

Results of Phase II trial of everolimus (Afinitor) presented at...

Neoadjuvant Everolimus in ER-positive Breast Cancer Patients

The mammalian target of rapamycin (mTOR), a kinase in...

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FLEX Study: KRAS Status Fails to Predict Cetuximab Response in Lung Cancer 

The multinational, randomized, Phase III FLEX study compared cisplatin...

Genomic Strategy in Modules of Oncogenic Pathway Signaling Networks

The phenotypic and molecular heterogeneity of human cancers is reflected ...

EGFR Mutations in Plasma Samples Predict Tumor Response in NSCLC Patients

Epidermal growth factor receptor (EGFR) is frequently over expressed ...

Predictive Role of Genetic Variants on the Outcome of mCRC

UGT1A1*28 is considered the main pharmacogenetic predictor of the toxicity ...
 

FDA Grants Full Approval for Sprycel for CML

Bristol-Myers Squibb announced that FDA has granted full approval...

Afinitor Recommended for Advanced RCC in EU

Novartis has received a positive opinion from the Committee for Medicinal Products ...

FDA Advisory Panel Makes Favorable Recommendation for ARZERRA 

GSK and Genmab announced that the FDA Oncologic Drugs Advisory Committee ...

NICE Recommends Erbitux for mCRC and Sutent for mRCC 

The National Institute for Health and Clinical Excellence (NICE) has published ...